- 专利标题： Inhibitors of farnesyl-protein transferase
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申请号： US831308申请日： 1997-04-01
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公开(公告)号： US5891889A公开(公告)日： 1999-04-06
- 发明人: Neville J. Anthony , Robert P. Gomez , John S. Wai , Mark W. Embrey , Thorsten E. Fisher
- 申请人： Neville J. Anthony , Robert P. Gomez , John S. Wai , Mark W. Embrey , Thorsten E. Fisher
- 申请人地址： NJ Rahway
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： NJ Rahway
- 主分类号： C07D211/62
- IPC分类号： C07D211/62 ; C07D401/06 ; C07D401/12 ; C07D401/14 ; C07D413/14 ; C07D401/08 ; A61K31/445
摘要：
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
公开/授权文献
- USD342877S Locking pliers 公开/授权日：1994-01-04