发明授权
US5891910A 9-halogen-(Z) prostaglandin derivatives, process for their production
and their use as pharmaceutical agents
失效
9-卤素 - （Z）前列腺素衍生物，其制备方法及其作为药剂的用途
- 专利标题： 9-halogen-(Z) prostaglandin derivatives, process for their production and their use as pharmaceutical agents
- 专利标题（中）： 9-卤素 - （Z）前列腺素衍生物，其制备方法及其作为药剂的用途
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申请号： US467888申请日： 1995-06-06
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公开(公告)号： US5891910A公开(公告)日： 1999-04-06
- 发明人: Bernd Buchmann , Werner Skuballa , Helmut Vorbrueggen , Bernd Raduechel , Olaf Loge , Walter Elger , Claus-Steffen Stuerzebecher , Karl-Heinz Thierauch
- 申请人： Bernd Buchmann , Werner Skuballa , Helmut Vorbrueggen , Bernd Raduechel , Olaf Loge , Walter Elger , Claus-Steffen Stuerzebecher , Karl-Heinz Thierauch
- 申请人地址： DEX
- 专利权人： Schering Aktiengesellschaft
- 当前专利权人： Schering Aktiengesellschaft
- 当前专利权人地址： DEX
- 优先权： DEX3724189.3 19870717; DEX3724190.7 19870717
- 主分类号： C07C405/00
- IPC分类号： C07C405/00 ; A61K31/557
摘要：
The invention relates to 9-halogen-(Z) prostane derivatives of formula I ##STR1## in which ##STR2## Z represents the radicals Hal represents a chlorine or fluorine atom,R.sub.1 represents ##STR3## A represents a --CH.sub.2 --CH.sub.2 --, a trans--CH=CH or --C.ident.C, W represents a free or a functionally modified ##STR4## group, D and E together represent a direct bond orD represents a straight-chain alkylene group with 1-10 C atoms, a branched-chain alkylene group with 2-10 C atoms or an annular alkylene group with 3-10 C atoms, which optionally can be substituted by fluorine atoms, andE represents an oxygen or sulfur atom, a direct bond, a C.ident.C bond or a --CR.sub.6 =CR.sub.7 group, and R.sub.6 and R.sub.7 are different and mean a hydrogen atom, a chlorine atom or a C.sub.1 -C.sub.4 alkyl group,R.sub.4 represents a free or functionally modified hydroxy,R.sub.5 means a hydrogen atom, an alkyl, a halogen-substituted alkyl, a cycloalkyl or an optionally substituted aryl or a heterocyclic group.
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