A method for automatically adjusting the parameters of a synthesizer includes generating a first synthesized signal based on an initial set of synthesizer parameters, comparing the first synthesized signal to an input sound signal, and generating a control signal for adjusting a subset of parameters of the synthesizer to minimize the differences between the first synthesized signal and the input sound signal. These steps may be iteratively performed for a predetermined number of additional subsets of synthesizer parameters, until a final output of the synthesizer is obtained which represents an optimization of the synthesis of the input sound signal.