A bioactive Factor produced, separated and isolated from either an aloe vera leaf or a product derived and processed from an aloe leaf, such as raw aloe vera gel, freeze-dried aloe vera gel extract, bulk acetylated mannan and bulk pharmaceutical mannan, utilizing different sizing processes, their processes or preparations, and their uses. The process of sizing can be accomplished by centrifugation, filtration, ultrafiltration, chromatography, dialysis, selective precipitation, pH adjustment, irradiation, homogenizing, or a combination of such processes. Compounding or mixing two or more different bioactive Factors from aloe at various concentration ratios, each Factor with its own specific bioactivity or bioactivities, to obtain a new bioactive Factor having desired optimal additive or synergistic effects.