发明授权
- 专利标题: Triazole derivatives
- 专利标题(中): 三唑衍生物
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申请号: US676350申请日: 1996-07-19
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公开(公告)号: US5902819A公开(公告)日: 1999-05-11
- 发明人: Victor Giulio Matassa , Francine Sternfeld , Leslie Joseph Street
- 申请人: Victor Giulio Matassa , Francine Sternfeld , Leslie Joseph Street
- 申请人地址: GBX Hoddesdon
- 专利权人: Merck Sharp & Dohme Ltd.
- 当前专利权人: Merck Sharp & Dohme Ltd.
- 当前专利权人地址: GBX Hoddesdon
- 优先权: GBX9402016 19940202
- 主分类号: C07D401/14
- IPC分类号: C07D401/14 ; A61K31/41 ; A61K31/44 ; A61K31/4427 ; A61P25/04 ; A61P25/06 ; A61P43/00 ; C07D403/14 ; C07D521/00
摘要:
Triazole derivatives represented by formula (IIA), and salts and prodrug thereof, wherein R.sup.1 represents C.sub.1-6 alkoxy(C.sub.1-6)alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.3-7 cycloalkyl, C.sub.3-7 cycloalkyl(C.sub.1-6)alkyl, aryl, aryl(C.sub.1-6)alkyl, aryloxy(C.sub.1-6)alkyl, aryl(C.sub.2-6)alkenyl, aryl(C.sub.2-6)alkynyl, C.sub.3-7 heterocycloalkyl(C.sub.1-6)alkyl, heteroaryl, heteroaryl(C.sub.1-6)alkyl, heteroaryl(C2-6)alkenyl or heteroaryl(C.sub.2-6)alkynyl, any of which groups may be optionally substituted; are selective agonist of 5-HT.sub.1 -like receptors and are therefore useful in the treatment of clinical conditions, in particular migraine and associated disorders, for which a selective agonist of these receptors is indicated. ##STR1##