The present invention is directed to a system and method of changing a cultural profile of a program, or application, while the program is executing in an information handling system. The system and method of the present invention enable programs to be globalized/localized to support many different countries and cultures. A user may dynamically change a program's cultural profile to a different cultural profile without having to reboot the system. The profile change may be accomplished through the use of a drag and drop interface. Different aspects, or windows, within a program may utilize different cultural profiles, and a cultural profile change to one aspect, or window, of the program does not affect the other aspects of the program. The present invention allows programs to be customized to support any culture or combination of cultures. This is accomplished through the use of a drag and drop interface, where cultural profiles, referred to as locale objects, are dropped onto windows within a program. When a locale object is dropped on a window, a message is sent to the window, and the window then updates its cultural profile information accordingly.