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US5912239A Imidazole-containing cationic amphiphiles for intracellular delivery of therapeutic molecules 失效
含咪唑的阳离子两亲物用于细胞内递送治疗分子

Imidazole-containing cationic amphiphiles for intracellular delivery of
therapeutic molecules
摘要:
Cationic amphiphiles are provided that facilitate transport of biologically active (therapeutic) molecules into cells. There are provided also therapeutic compositions prepared typically by contacting a dispersion of one or more cationic amphiphiles with the therapeutic molecules. Therapeutic molecules that can be delivered into cells according to the practice of the invention include DNA, RNA, and polypeptides. Representative uses of the therapeutic compositions of the invention include providing gene therapy, and delivery of antisense polynucleotides or biologically active polypeptides to cells. With respect to therapeutic compositions for gene therapy, the DNA is provided typically in the form of a plasmid for complexing with the cationic amphiphile.
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