发明授权
- 专利标题: Imidazole-containing cationic amphiphiles for intracellular delivery of therapeutic molecules
- 专利标题(中): 含咪唑的阳离子两亲物用于细胞内递送治疗分子
-
申请号: US833370申请日: 1997-04-04
-
公开(公告)号: US5912239A公开(公告)日: 1999-06-15
- 发明人: Craig S. Siegel , Edward R. Lee , David J. Harris
- 申请人: Craig S. Siegel , Edward R. Lee , David J. Harris
- 申请人地址: MA Boston
- 专利权人: Genzyme Corporation
- 当前专利权人: Genzyme Corporation
- 当前专利权人地址: MA Boston
- 主分类号: A61K9/127
- IPC分类号: A61K9/127 ; C07J43/00 ; A61K31/575
摘要:
Cationic amphiphiles are provided that facilitate transport of biologically active (therapeutic) molecules into cells. There are provided also therapeutic compositions prepared typically by contacting a dispersion of one or more cationic amphiphiles with the therapeutic molecules. Therapeutic molecules that can be delivered into cells according to the practice of the invention include DNA, RNA, and polypeptides. Representative uses of the therapeutic compositions of the invention include providing gene therapy, and delivery of antisense polynucleotides or biologically active polypeptides to cells. With respect to therapeutic compositions for gene therapy, the DNA is provided typically in the form of a plasmid for complexing with the cationic amphiphile.
公开/授权文献
- US5393001A Core chuck for coil winding 公开/授权日:1995-02-28
信息查询