发明授权
- 专利标题: Thiadiazoleamide derivative and anti-ulcer drug
- 专利标题(中): 噻二唑衍生物和抗溃疡药
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申请号: US157376申请日: 1998-09-21
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公开(公告)号: US5912258A公开(公告)日: 1999-06-15
- 发明人: Chikao Nishino , Fumitaka Sato , Tomohiro Uetake , Hirotada Fukunishi , Nao Kojima
- 申请人: Chikao Nishino , Fumitaka Sato , Tomohiro Uetake , Hirotada Fukunishi , Nao Kojima
- 申请人地址: JPX Tokyo
- 专利权人: Shiseido Co., Ltd.
- 当前专利权人: Shiseido Co., Ltd.
- 当前专利权人地址: JPX Tokyo
- 主分类号: C07D285/12
- IPC分类号: C07D285/12 ; C07D285/135 ; C07D417/12 ; C07D289/135 ; A61K31/41
摘要:
A thiadiazoleamide derivative or a salt thereof expressed by the following Formula 1: ##STR1## wherein each of R.sub.1 and R.sub.2 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylamino group or an alkenyloxy group; wherein when either R.sub.1 or R.sub.2 is a hydrogen atom, the other is not a hydrogen atom; R.sub.3 represents a lower alkyl group, an aryl group, a pyridyl group or --N(R.sub.4)R.sub.5, wherein R.sub.4 and R.sub.5 represent lower alkyl groups or together represent a saturated heterocyclic ring having 4-8 members; wherein when R.sub.1 or R.sub.2 is a lower alkoxy group, R.sub.3 is --N(R.sub.4)R.sub.5 or a pyridyl group; and n represents an integer of 1-3. The derivatives have anti-ulcer effect to be available for preventing or curing ulcers in mammals.