发明授权
US5917055A Process for producing
N-(D-.alpha.-methyl-.beta.-mercaptopropionyl)-L-proline and its
intermediate
失效
制备N-（D-α-甲基-β-巯基丙酰基）-L-脯氨酸及其中间体的方法
- 专利标题： Process for producing N-(D-.alpha.-methyl-.beta.-mercaptopropionyl)-L-proline and its intermediate
- 专利标题（中）： 制备N-（D-α-甲基-β-巯基丙酰基）-L-脯氨酸及其中间体的方法
-
申请号： US849337申请日： 1997-07-31
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公开(公告)号： US5917055A公开(公告)日： 1999-06-29
- 发明人: Yasuyoshi Ueda , Fumihiko Kanou , Koichi Kinoshita , Takahiro Okubo
- 申请人： Yasuyoshi Ueda , Fumihiko Kanou , Koichi Kinoshita , Takahiro Okubo
- 申请人地址： JPX Osaka
- 专利权人： Kaneka Corporation
- 当前专利权人： Kaneka Corporation
- 当前专利权人地址： JPX Osaka
- 优先权： JPX7-286886 19951006; JPX8-122727 19960419
- 主分类号： A61K31/00
- IPC分类号： A61K31/00 ; C07D207/16
摘要：
A highly convenient and efficient process for economically producing in a high yield high-quality captopril which is remarkably reduced in the content of impurities and has a high melting point and intermediates for synthesizing the same which contain only a small amount of precursors as impurities and have excellent qualities. The process comprises subjecting an acid halide and an L-proline to the Schotten-Baumann reaction and eliminating the impurities formed as the by-products in the form of the precursors represented by general formula (5) or (6) by treating, during or after the Schotten-Baumann reaction, the aqueous medium solution with active carbon or crystallization followed by deacylation. In the formula, R.sup.1 represents acyl and n represents an integer of from 2 to 4. ##STR1##
公开/授权文献
- US4810786A Stabilization of xanthan gum in aqueous solution 公开/授权日：1989-03-07
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