发明授权
US5919434A Polymeric surfactant-encapsulated microbubbles and their use in
ultrasound imaging
失效
聚合物表面活性剂包封的微泡及其在超声成像中的应用
- 专利标题: Polymeric surfactant-encapsulated microbubbles and their use in ultrasound imaging
- 专利标题(中): 聚合物表面活性剂包封的微泡及其在超声成像中的应用
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申请号: US602797申请日: 1997-03-14
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公开(公告)号: US5919434A公开(公告)日: 1999-07-06
- 发明人: Harald Dugstad , Per Antonius Foss , Jo Klaveness , P.ang.l Rongved , Roald Skurtveit
- 申请人: Harald Dugstad , Per Antonius Foss , Jo Klaveness , P.ang.l Rongved , Roald Skurtveit
- 申请人地址: NOX Oslo
- 专利权人: Nycomed Imaging AS
- 当前专利权人: Nycomed Imaging AS
- 当前专利权人地址: NOX Oslo
- 优先权: GBX9318288 19930903
- 主分类号: A61K49/00
- IPC分类号: A61K49/00 ; A61K49/04 ; A61K49/22 ; B01F17/00 ; B01J13/04 ; C08G63/08 ; A61K9/16 ; B01J13/02 ; B32B5/16
摘要:
The present invention relates to polymer-based gas-containing contrast agents in which microbubbles of gas are encapsulated by non-polymerizable wall-forming block or graft copolymer surfactants. The polymer surfactants are preferably biodegradable and include block and graft copolymers containing linkages of formula (I):--(O).sub.m --CO--O--C(R.sup.1 R.sup.2)--O--CO--(O).sub.n --(I)where R.sup.1 and R.sup.2 each represent a hydrogen atom or a carbon-attached monovalent organic group, or R.sup.1 and R.sup.2 together form a carbon-attached divalent organic group and m and n are each zero or 1.
公开/授权文献
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