发明授权
US5919434A Polymeric surfactant-encapsulated microbubbles and their use in ultrasound imaging 失效
聚合物表面活性剂包封的微泡及其在超声成像中的应用

Polymeric surfactant-encapsulated microbubbles and their use in
ultrasound imaging
摘要:
The present invention relates to polymer-based gas-containing contrast agents in which microbubbles of gas are encapsulated by non-polymerizable wall-forming block or graft copolymer surfactants. The polymer surfactants are preferably biodegradable and include block and graft copolymers containing linkages of formula (I):--(O).sub.m --CO--O--C(R.sup.1 R.sup.2)--O--CO--(O).sub.n --(I)where R.sup.1 and R.sup.2 each represent a hydrogen atom or a carbon-attached monovalent organic group, or R.sup.1 and R.sup.2 together form a carbon-attached divalent organic group and m and n are each zero or 1.
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