发明授权
US5932729A 1-(N'-(arylalkylaminoalkyl)) aminoisoindoles; a new class of dopamine
receptor subtype specific ligands
失效
1-(N' - (芳基烷基氨基烷基))氨基异吲哚; 一类新的多巴胺受体亚型特异性配体
- 专利标题: 1-(N'-(arylalkylaminoalkyl)) aminoisoindoles; a new class of dopamine receptor subtype specific ligands
- 专利标题(中): 1-(N' - (芳基烷基氨基烷基))氨基异吲哚; 一类新的多巴胺受体亚型特异性配体
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申请号: US907402申请日: 1997-08-07
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公开(公告)号: US5932729A公开(公告)日: 1999-08-03
- 发明人: Xiao-shu He , Brian de Costa , Jan W. F. Wasley
- 申请人: Xiao-shu He , Brian de Costa , Jan W. F. Wasley
- 申请人地址: CT Branford
- 专利权人: Neurogen Corporation
- 当前专利权人: Neurogen Corporation
- 当前专利权人地址: CT Branford
- 主分类号: C07D209/44
- IPC分类号: C07D209/44 ; C07D401/12 ; C07D403/12 ; C07D401/14 ; C07D403/14
摘要:
Disclosed are compounds of the formula ##STR1## or the pharmaceutically acceptable salts thereof wherein the 6-membered A ring may be optionally substituted with up to four groups independently selected from halogen, hydroxy, lower alkyl, or lower alkoxy;Ar represents optionally substituted aryl or heteroaryl;Z represents carbon or nitrogen provided thatwhere Z is carbon, R.sub.11 represents hydrogen, halogen, hydroxy, lower alkyl, or lower alkoxy, or phenyl optionally substituted with one or two groups selected from hydrogen, halogen, hydroxy, lower alkyl, or lower alkoxy; andwhere Z is nitrogen, R.sub.11 represents an electron pair;R.sub.5 is hydrogen or lower alkyl;L and m represent integers;n is 0, or an integer;R.sub.12 and R.sub.13 independently represent lower alkyl; or together may together form an optionally substituted 5-11 membered ring with the nitrogen atoms to which they are bonded; CR'R" represents a methylene group optionally substituted with lower alkyl; andk is an integer of from 1 to 3,which compounds are useful in treating various neuropsychochological disorders including, for example, schizophrenia, dementia, depression, anxiety, Parkinson-like motor disorders and motion disorders related to the use of neuroleptic agents.
公开/授权文献
- US5281869A Reduced-voltage NMOS output driver 公开/授权日:1994-01-25
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