A computer docking station is provided which, in a disclosed embodiment thereof, includes multiple security features. The security features are operable to prevent access to interior portions of the docking station, prevent access to a card bay of the docking station, prevent ejection of a disk drive from a disk drive module of the docking station, and prevent operation of the disk drive module. Operation of the security features may be simultaneously and conveniently initiated by rotating a keyed lock mechanism to thereby rotate a cam mounted thereto.