发明授权
US5936078A DNA and protein for the diagnosis and treatment of Alzheimer's disease
失效
DNA和蛋白质用于诊断和治疗阿尔茨海默病
- 专利标题： DNA and protein for the diagnosis and treatment of Alzheimer's disease
- 专利标题（中）： DNA和蛋白质用于诊断和治疗阿尔茨海默病
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申请号： US909965申请日： 1997-08-12
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公开(公告)号： US5936078A公开(公告)日： 1999-08-10
- 发明人: Tetsuro Kuga , Satoshi Nakagawa , Yoshiyuki Sakaki , Nanding Zhao , Hideji Hashida
- 申请人： Tetsuro Kuga , Satoshi Nakagawa , Yoshiyuki Sakaki , Nanding Zhao , Hideji Hashida
- 申请人地址： JPX Tokyo
- 专利权人： Kyowa Hakko Kogyo Co., Ltd.
- 当前专利权人： Kyowa Hakko Kogyo Co., Ltd.
- 当前专利权人地址： JPX Tokyo
- 优先权： JPX7-322745 19951212
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07K14/47 ; C12N15/12 ; C07H21/04
摘要：
The present invention relates to a DNA selected from DNAs, each having the nucleotide sequence of one of Sequence Nos. 1 to 17, complementary to the RNA strand of mRNA with the varied expression level in patients with Alzheimer's disease, compared with the expression level of the mRNA in normal human brain or a DNA hybridizable with the above-mentioned DNA wherein one or more nucleotides in said DNA are deleted or substituted with other nucleotides or one or more nucleotides are added to said DNA, a polypeptide encoded by the DNA, an antibody recognizing the polypeptide, and the diagnosis, therapeutic treatment and research works of patients with Alzheimer's disease, using the DNA, the polypeptide and the antibody.
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