A method of manufacturing a shoe lining having anti-microbial properties. The method comprises providing a quantity of a thermoplastic resin including an inorganic zinc-based anti-microbial agent admixture having a predetermined microbial inhibition characteristic. This thermoplastic resin is blended with a polyethylene resin to form an anti-microbial feedstock. The anti-microbial feedstock is formed into relatively long, narrow, thin lengths of anti-microbial members. These members are woven into an anti-microbial fabric having predetermined microbial inhibition characteristics. This fabric is cut into a plurality of pieces in accordance with a predetermined pattern and the pieces are joined together thereby constructing the anti-microbial shoe lining.