发明授权
- 专利标题： High affinity nucleic acid ligands containing modified nucleotides
- 专利标题（中）： 含有修饰的核苷酸的高亲和力核酸配体
-
申请号： US918304申请日： 1997-08-25
-
公开(公告)号： US5958691A公开(公告)日： 1999-09-28
- 发明人: Wolfgang Pieken , Diane Tasset , Nebojsa Janjic , Larry Gold , Gary P. Kirschenheuter
- 申请人： Wolfgang Pieken , Diane Tasset , Nebojsa Janjic , Larry Gold , Gary P. Kirschenheuter
- 申请人地址： CO Boulder
- 专利权人： NeXstar Pharmaceuticals, Inc.
- 当前专利权人： NeXstar Pharmaceuticals, Inc.
- 当前专利权人地址： CO Boulder
- 主分类号： C07B61/00
- IPC分类号： C07B61/00 ; C07H19/06 ; C07H19/10 ; C07H21/00 ; C12N15/10 ; C12N15/115 ; C12Q1/68 ; C40B40/02 ; G01N33/531 ; G01N33/569 ; G01N33/76 ; C07H21/02 ; C07H21/04 ; C12P19/34
摘要：
Nucleic acid ligands containing modified nucleotides are described as are methods for producing such oligonucleotides. Such ligands enrich the chemical diversity of the candidate mixture for the SELEX process. Specific examples are provided of nucleic acids containing nucleotides modified at the 2'- and 5-position. Specific 2-OH and 2'-NH.sub.2 modified RNA ligands to thrombin are described.
公开/授权文献
- US5264325A Composition for photo imaging 公开/授权日：1993-11-23