发明授权
- 专利标题: Process for producing cis-3-hydroxy-L-proline
- 专利标题(中): 顺式-3-羟基-L-脯氨酸的制备方法
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申请号: US708856申请日: 1996-09-09
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公开(公告)号: US5962292A公开(公告)日: 1999-10-05
- 发明人: Akio Ozaki , Hideo Mori , Takeshi Shibasaki , Katsuhiko Ando , Keiko Ochiai , Shigeru Chiba , Yoichi Uosaki
- 申请人: Akio Ozaki , Hideo Mori , Takeshi Shibasaki , Katsuhiko Ando , Keiko Ochiai , Shigeru Chiba , Yoichi Uosaki
- 申请人地址: JPX Tokyo
- 专利权人: Kyowa Hakko Kogyo Co., Ltd.
- 当前专利权人: Kyowa Hakko Kogyo Co., Ltd.
- 当前专利权人地址: JPX Tokyo
- 优先权: JPX5-221941 19930907
- 主分类号: C12N9/02
- IPC分类号: C12N9/02 ; C12P13/24 ; C07H21/04 ; C12N1/20 ; C12N15/00
摘要:
An industrially applicable process for producing cis-3-hydroxy-L-proline, which is useful as a raw material for medicines or as an additive to foods. In the process, L-proline is converted into cis-3-hydroxy-L-proline in the presence of an enzyme source which is derived from a microorganism belonging to the genus Streptomyces or Bacillus and which catalyzes hydroxylation of L-proline into cis-3-hydroxy-L-proline, a divalent iron ion and 2-ketoglutaric acid, in an aqueous medium, and the produced cis-3-hydroxy-L-proline is collected from the aqueous medium. A novel enzyme L-proline-3-hydroxylase, a gene of L-proline-3-hydroxylase which is useful for the process, a transformant containing the gene, and a process for producing L-proline-3-hydroxylase using the transformant.
公开/授权文献
- US4667198A Apparatus for measuring quantity of AC electricity 公开/授权日:1987-05-19