发明授权
US5962465A Aminomethyl-2,3,8,9-tetrahydro-7H-1,4-dioxino-�2,3-e!-indol-8-ones and
derivatives
失效
氨基甲基-2,3,8,9-四氢-7H-1,4-二氧杂 - [2,3-e] - 吲哚-8-酮和衍生物
- 专利标题: Aminomethyl-2,3,8,9-tetrahydro-7H-1,4-dioxino-�2,3-e!-indol-8-ones and derivatives
- 专利标题(中): 氨基甲基-2,3,8,9-四氢-7H-1,4-二氧杂 - [2,3-e] - 吲哚-8-酮和衍生物
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申请号: US15149申请日: 1998-01-29
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公开(公告)号: US5962465A公开(公告)日: 1999-10-05
- 发明人: Gary P. Stack , Richard E. Mewshaw , Byron A. Bravo , Young H. Kang
- 申请人: Gary P. Stack , Richard E. Mewshaw , Byron A. Bravo , Young H. Kang
- 申请人地址: NJ Madison
- 专利权人: American Home Products Corporation
- 当前专利权人: American Home Products Corporation
- 当前专利权人地址: NJ Madison
- 主分类号: A61K31/357
- IPC分类号: A61K31/357 ; A61K31/40 ; A61K31/407 ; A61K31/4439 ; A61P25/00 ; A61P25/16 ; A61P25/18 ; A61P43/00 ; C07D209/60 ; C07D405/14 ; C07D409/14 ; C07D491/04 ; C07D491/056 ; C07D491/113 ; A61K31/47
摘要:
The compounds of formula I: ##STR1## wherein R.sup.1 and R.sup.2 are, independently, hydrogen, alkyl, phenyl or benzyl; or R.sup.1 and R.sup.2, taken together, are benzylidene optionally substituted with R.sup.3 as defined below or alkylidene, or R.sup.1 and R.sup.2, taken together with the carbon to which they are attached, form a carbonyl moiety or a cycloalkyl group; R.sup.3 is hydrogen, hydroxy, halo, trifluoromethyl, trifluoromethoxy, alkyl, alkoxy, aralkoxy, alkanoyloxy, amino, mono- or di-alkylamino, alkanamido or alkanesulfonamido; R.sup.4 is hydrogen or alkyl; m is an integer 0, 1 or 2; n is an integer from 0 to 6, inclusive; Z is hydrogen, hydroxy, alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, polycyclo-alkyl, phenyl optionally substituted with R.sup.3 as defined above, phenoxy optionally substituted with R.sup.3 as defined above, naphthyl optionally substituted with R.sup.3 as defined above or naphthyloxy optionally substituted with R.sup.3 as defined above, heteroaryl or heteroaryloxy, in which the heterocyclic ring of the heteroaryl or heteroaryloxy group is selected from thiophene, furan, pyridine, pyrazine, pyrimidine, indole, indazole, imidazole, chroman, coumarin, carbostyril, quinoline, benzisoxazole, benzoxazole, pyrazole, pyrrole, thiazole, oxazole, or isoxazole and the heterocyclic ring is optionally substituted by R.sup.3 as defined above; or a pharmaceutically acceptable salt thereof, are useful in treating disorders of the dopaminergic system.
公开/授权文献
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