发明授权
US5962490A Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that
modulate the activity of endothelin
失效
调节内皮素活性的噻吩基，呋喃基和吡咯基磺酰胺及其衍生物
- 专利标题： Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
- 专利标题（中）： 调节内皮素活性的噻吩基，呋喃基和吡咯基磺酰胺及其衍生物
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申请号： US721183申请日： 1996-09-27
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公开(公告)号： US5962490A公开(公告)日： 1999-10-05
- 发明人: Ming Fai Chan , Chengde Wu , Bore Gowda Raju , Timothy Kogan , Adam Kois , Erik Joel Verner , Rosario Silvestre Castillo , Venkatachalapathi Yalamorri , Vitukudi Narayanaiyengar Balaji
- 申请人： Ming Fai Chan , Chengde Wu , Bore Gowda Raju , Timothy Kogan , Adam Kois , Erik Joel Verner , Rosario Silvestre Castillo , Venkatachalapathi Yalamorri , Vitukudi Narayanaiyengar Balaji
- 申请人地址： TX Houston
- 专利权人： Texas Biotechnology Corporation
- 当前专利权人： Texas Biotechnology Corporation
- 当前专利权人地址： TX Houston
- 主分类号： C07D419/12
- IPC分类号： C07D419/12 ; A61K31/381 ; A61K31/42 ; A61K31/422 ; A61K31/423 ; A61K31/433 ; A61K31/496 ; A61P1/00 ; A61P9/00 ; A61P9/10 ; A61P9/12 ; A61P11/06 ; A61P11/08 ; A61P13/12 ; A61P15/00 ; A61P27/02 ; A61P29/00 ; A61P43/00 ; C07D261/10 ; C07D409/12 ; C07D413/12 ; C07D413/14 ; C07D417/12
摘要：
Thienyl-, furyl- and pyrrolyl-sulfonamides and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, N-(isoxazolyl)thienylsulfonamides, N-(isoxazolyl)-furylsulfonamides and N-(isoxazolyl)pyrrolylsulfonamides and methods using these sulfonamides for inhibiting the binding of an endothelin peptide to an endothelin receptor by contacting the receptor with the sulfonamide are provided. Methods for treating endothelin-mediated disorders by administering effective amounts of one or more of these sulfonamides or prodrugs thereof that inhibit or increase the activity of endothelin are also provided.
公开/授权文献
- US4711834A Laser-imageable assembly and process for production thereof 公开/授权日：1987-12-08