发明授权
- 专利标题: Piperidines promote release of growth hormone
- 专利标题(中): 皮质激素促进生长激素的释放
-
申请号: US988816申请日: 1997-12-11
-
公开(公告)号: US5965565A公开(公告)日: 1999-10-12
- 发明人: Meng H. Chen , Zhijian Lu , Ravi Nargund , Arthur A. Patchett , James R. Tata , Lihu Yang , Mu Tsu Wu
- 申请人: Meng H. Chen , Zhijian Lu , Ravi Nargund , Arthur A. Patchett , James R. Tata , Lihu Yang , Mu Tsu Wu
- 申请人地址: NJ Rahway
- 专利权人: Merck & Co., Inc.
- 当前专利权人: Merck & Co., Inc.
- 当前专利权人地址: NJ Rahway
- 主分类号: C07D401/06
- IPC分类号: C07D401/06 ; C07D413/14 ; C07D471/10 ; C07D495/10 ; C07D209/04 ; A61K31/445 ; C07D211/00
摘要:
The present invention is directed to certain piperidines, pyrrolidines, and hexahydro-1H-azepines of the general structural formula: ##STR1## wherein B is selected from: ##STR2## and R.sup.1, R.sup.1a, R.sup.2a, R.sup.3a, R.sup.3b, R.sup.4, R.sup.4a, R.sup.4b, R.sup.4c, R.sup.5, D, X, Y, n, x and y are as defined herein. These compounds promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such compounds as the active ingredient thereof are also disclosed.