发明授权
- 专利标题： Antisense oligonucleotide modulation of human HER-2 expression
- 专利标题（中）： 人HER-2表达的反义寡核苷酸调节
-
申请号： US48804申请日： 1998-03-26
-
公开(公告)号： US5968748A公开(公告)日： 1999-10-19
- 发明人: C. Frank Bennett , Allan Lipton , Lois M. Witters
- 申请人： C. Frank Bennett , Allan Lipton , Lois M. Witters
- 申请人地址： CA Carlsbad PA University Park
- 专利权人： Isis Pharmaceuticals, Inc.,The Penn State Research Foundation
- 当前专利权人： Isis Pharmaceuticals, Inc.,The Penn State Research Foundation
- 当前专利权人地址： CA Carlsbad PA University Park
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C12N15/113 ; C12Q1/68 ; C07H21/04 ; C12N15/85
摘要：
Compounds, compositions and methods are provided for inhibiting the expression of human HER-2 (also known as c-neu, ErbB-2 and HER-2/neu). The compositions comprise antisense oligonucleoptides targeted to nucleic acids encoding HER-2. Methods of using these oligonucleotides for inhibition of HER-2 expression and for treatment of diseases such as cancers associated with overexpression of HER-2 are provided. Methods of inhibiting other growth factor receptors using antisense oligonucleotides targeted to nucleic acids encoding HER-2 are also provided.
公开/授权文献
- USD376840S Refillable toilet tank dispenser 公开/授权日：1996-12-24
信息查询
IPC分类:
