发明授权
US5977367A N-aminoalkyldibenzofurancarboxamides; new dopamine receptor subtype
specific ligands
失效
N-氨基烷基二苯并呋喃甲酰胺; 新的多巴胺受体亚型特异性配体
- 专利标题: N-aminoalkyldibenzofurancarboxamides; new dopamine receptor subtype specific ligands
- 专利标题(中): N-氨基烷基二苯并呋喃甲酰胺; 新的多巴胺受体亚型特异性配体
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申请号: US005285申请日: 1998-01-09
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公开(公告)号: US5977367A公开(公告)日: 1999-11-02
- 发明人: Jun Yuan , Xi Chen
- 申请人: Jun Yuan , Xi Chen
- 申请人地址: CT Branford
- 专利权人: Neurogen Corporation
- 当前专利权人: Neurogen Corporation
- 当前专利权人地址: CT Branford
- 主分类号: A61K31/34
- IPC分类号: A61K31/34 ; A61K31/343 ; A61K31/443 ; A61K31/4525 ; A61K31/496 ; A61P25/00 ; A61P25/18 ; A61P25/24 ; A61P25/26 ; A61P25/28 ; A61P43/00 ; C07D307/91 ; C07D405/12
摘要:
Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable acid addition salts thereof, wherein: R.sub.1, R.sub.2, R.sub.3, R.sub.4 are the same or different and represent hydrogen, C.sub.1 -C.sub.6 alkyl, halogen, hydroxy, amino, cyano, nitro, trifluoromethyl, trifluoromethoxy, C.sub.1 -C.sub.6 alkoxy, --O.sub.2 CR', --NHCOR', --COR', --SO.sub.m R', where R' is C.sub.1 -C.sub.6 alkyl and wherein m is 0, 1 or 2; orR.sub.1, R.sub.2, R.sub.3, R.sub.4 independently represent --CONR'.sub.m, or --NR'.sub.m where m is 0, 1 or 2 and R' is hydrogen or C.sub.1 -C.sub.6 alkyl;R.sub.5 is hydrogen or C.sub.1 -C.sub.6 alkyl; andR represents an aminoalkyl group,which compounds are useful in the treatment of affective disorders such as schizophrenia, depression, Alzheimer's disease, movement disorders such as Parkinsonism and dystonia, and other disorders which respond to dopaminergic blockade such as substance abuse and obsessive compulsive disorders. Further, compounds of this invention may be useful in treating the extrapyramidal side effects associated with the use of conventional neuroleptic agents.
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