发明授权
- 专利标题: Polynucleotide encoding chemokine .beta.-4
- 专利标题(中): 多核苷酸编码趋化因子β-4
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申请号: US458355申请日: 1995-06-02
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公开(公告)号: US5981230A公开(公告)日: 1999-11-09
- 发明人: Haodong Li , Mark D. Adams
- 申请人: Haodong Li , Mark D. Adams
- 申请人地址: MD Rockville
- 专利权人: Human Genome Sciences, Inc.
- 当前专利权人: Human Genome Sciences, Inc.
- 当前专利权人地址: MD Rockville
- 主分类号: C07K14/52
- IPC分类号: C07K14/52 ; C12N15/19 ; C12N15/63
摘要:
Human chemokine polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
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