发明授权
- 专利标题: C-terminal sequencing of peptides which may include proline
- 专利标题(中): 肽的C末端测序可能包括脯氨酸
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申请号: US532667申请日: 1995-11-09
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公开(公告)号: US5998213A公开(公告)日: 1999-12-07
- 发明人: Jerome M. Bailey , John E. Shively
- 申请人: Jerome M. Bailey , John E. Shively
- 申请人地址: CA Duarte
- 专利权人: City of Hope
- 当前专利权人: City of Hope
- 当前专利权人地址: CA Duarte
- 主分类号: C07K1/12
- IPC分类号: C07K1/12 ; G01N33/68
摘要:
A carboxy terminal protein sequencing process is disclosed which utilizes diphenyl phosphoroisothiocyanatidate and a heterocyclic amine to produce a thiohydantoin derivative of the C-terminal amino acid. The derivative is readily cleaved. The method is useful to sequence through all of the 20 naturally occuring amino acids.
公开/授权文献
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