发明授权
- 专利标题： Polymeric lamellar substrate particles for drug delivery
- 专利标题（中）： 用于药物递送的聚合物层状底物颗粒
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申请号： US983156申请日： 1998-03-30
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公开(公告)号： US6001395A公开(公告)日： 1999-12-14
- 发明人: Allan Gerald Arthur Coombes , Stanley Stewart Davis , Diane Lisa Major , John Michael Wood
- 申请人： Allan Gerald Arthur Coombes , Stanley Stewart Davis , Diane Lisa Major , John Michael Wood
- 申请人地址： GBX Nottingham
- 专利权人： Danbiosyst UK Limited
- 当前专利权人： Danbiosyst UK Limited
- 当前专利权人地址： GBX Nottingham
- 优先权： GBX9514285 19950713
- 主分类号： A61K9/00
- IPC分类号： A61K9/00 ; A61K9/14 ; A61K9/16 ; A61K31/70 ; A61K38/00 ; A61K38/04 ; A61K38/22 ; A61K38/27 ; A61K38/28 ; A61K39/00 ; A61K39/08 ; A61K39/145 ; A61K39/35 ; A61K47/34 ; A61K47/48
摘要：
The invention provides a composition for delivery of an active agent comprising a plurality of lamellar particles of a biodegradable polymer which is at least in part crystalline, and an active agent adsorbed to at least most of the particles. Preferably the biodegradablepolymer is at least 5% by weight crystalline. Preferred biodegradable polymers are poly(L-lactide) (L.PLA) or copolymers or blends of L.PLA. The particles are especially useful for the immobilization of antigens or allergens for vaccines.
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