发明授权
US06008247A 2,4-bis[(4-amidino)phenyl]furans as anti-Pneumocystis carinii agents
失效
2,4-二[(4-脒基)苯基]呋喃作为抗肺孢子虫卡尼氏菌剂
- 专利标题: 2,4-bis[(4-amidino)phenyl]furans as anti-Pneumocystis carinii agents
- 专利标题(中): 2,4-二[(4-脒基)苯基]呋喃作为抗肺孢子虫卡尼氏菌剂
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申请号: US32586申请日: 1998-02-27
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公开(公告)号: US06008247A公开(公告)日: 1999-12-28
- 发明人: David W. Boykin , Richard R. Tidwell , W. David Wilson , Iris Francesconi
- 申请人: David W. Boykin , Richard R. Tidwell , W. David Wilson , Iris Francesconi
- 申请人地址: NC Chapel Hill GA Atlanta
- 专利权人: The University of North Carolina at Chapel Hill,Georgia State University
- 当前专利权人: The University of North Carolina at Chapel Hill,Georgia State University
- 当前专利权人地址: NC Chapel Hill GA Atlanta
- 主分类号: A61K31/34
- IPC分类号: A61K31/34 ; A61K31/341 ; A61P11/00 ; A61P29/00 ; A61P33/02 ; C07D307/52 ; C07D307/54 ; C07D405/10 ; C07D405/14 ; C07D233/06 ; C07D307/08
摘要:
Compounds according to the formula: ##STR1## wherein: R.sub.1 and R.sub.2 are each independently selected from the group consisting of H, loweralkyl, aryl, alkylaryl, aminoalkyl, aminoaryl, halogen, oxyalkyl, oxyaryl, or oxyarylalkyl; R.sub.3 and R.sub.4 are each independently selected from the group consisting of H, loweralkyl, oxyalkyl, alkylaryl, aryl, oxyaryl, aminoalkyl, aminoaryl, or halogen; and X and Y are located in the para or meta positions and are each selected from the group consisting of H, loweralkyl, oxyalkyl, and ##STR2## wherein: each R.sub.5 is independently selected from the group consisting of H, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, or alkylaryl or two R.sub.5 groups together represent C.sub.2 to C.sub.10 alkyl, hydroxyalkyl, or alkylene; and R.sub.6 is H, hydroxy, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylamino, lkylarninoalkyl, cycloalkyl, hydroxycycloalkyl, alkoxycycloalkyl, aryl, or alkylaryl; or a pharmaceutically acceptable salt thereof, are disclosed. The compounds are useful for treating Pneumocystis carinii in a subject in need of such treatment.
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