发明授权
- 专利标题： Nucleic acids encoding HST 2 muteins
- 专利标题（中）： 核酸编码HST 2突变蛋白
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申请号： US902233申请日： 1997-07-29
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公开(公告)号： US6013784A公开(公告)日： 2000-01-11
- 发明人: Koji Yoshimura , Kaori Ishimaru , Koichi Igarashi , Masaaki Terada
- 申请人： Koji Yoshimura , Kaori Ishimaru , Koichi Igarashi , Masaaki Terada
- 申请人地址： JPX Tokyo
- 专利权人： President of National Cancer Center
- 当前专利权人： President of National Cancer Center
- 当前专利权人地址： JPX Tokyo
- 优先权： JPX5-024399 19930212; JPX5-186507 19930728
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07K14/50 ; C12N15/16 ; C12N5/10 ; C12N15/12 ; C12N15/63
摘要：
The present invention provides a polypeptide represented by the following amino acid sequence:(Met)n=X=Leu=Ala=Gly=Glu=Ile=Ala=Gly=Val=Asn - Trp=Glu=Ser - Gly=Tyr=Leu=Val=Gly=Ile=Lys=Arg=Gln=Arg=Arg - Leu=Tyr=Cys=Asn - Val=Gly=Ile=Gly=Phe=His=Leu=Gln=Val=Leu=Pro - Asp=Gly=Arg=Ile - Ser=Gly=Thr=His=Glu=Glu=Asn=Pro=Tyr=Ser=Leu - Leu=Glu=Ile=Ser - Thr=Val=Glu=Arg=Gly=Val=Val=Ser=Leu=Phe=Gly - Val=Arg=Ser=Ala - Leu=Phe=Val=Ala=Met=Asn=Ser=Lys=Gly=Arg=Leu - Tyr=Ala=Thr=Pro - Ser=Phe=Gin=Glu=Glu=Cys=Lys=Phe=Arg=Glu=Thr Leu=Leu=Pro=Asn - Asn=Tyr=Asn=Ala=Tyr=Glu=Ser=Asp=Leu=Tyr=Gln - Gly=Thr=Tyr=Ile - Ala=Leu=Ser=Lys=Tyr=Gly=Arg=Val=Lys=Arg=Gly - Ser=Lys=Val=Ser - Pro=Ile=Met=Thr=Val=Thr=His=Phe=Leu=Pro=Arg=Ile wherein n is 0 or 1 and X represents Pro Ala Gly Thr Arg Ala Asn Asn Thr Leu Leu Asp Ser Arg Gly Trp Gly Thr Leu Leu Ser Arg Ser Arg Ala Gly or a fragment thereof (n=0: SEQ ID NO: 1, n=1: SEQ ID NO: 2), a recombinant DNA coding for the polypeptide, a vector containing the recombinant DNA, the preparation of a transformant carrying the vector, and the production of the polypeptide with the transformant.