发明授权
- 专利标题： Quinazoline derivative
- 专利标题（中）： 喹唑啉衍生物
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申请号： US930042申请日： 1997-09-26
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公开(公告)号： US06015814A公开(公告)日： 2000-01-18
- 发明人: Andrew John Barker
- 申请人： Andrew John Barker
- 申请人地址： GBX London
- 专利权人： Zeneca Limited
- 当前专利权人： Zeneca Limited
- 当前专利权人地址： GBX London
- 优先权： GBX9508565 19950427
- 主分类号： A61K31/505
- IPC分类号： A61K31/505 ; A61K31/517 ; A61P35/00 ; A61P43/00 ; C07D239/94 ; A01N43/54 ; C07D239/72
摘要：
The invention concerns derivatives of the formula wherein n is 1, 2 or 3 and each R.sup.2 is independently halogeno; and R.sup.1 is amino-(2-4C)alkylamino, (1-4C)alkylamino, (1-4C)alkylamino-(2-4C)alkylamino,di-[(1-4C)alkyl]amino-(2-4C) alkylamino, pyrrolidin-1-yl-(2-4C)alkylamino, piperidino-(2-4C)alkylamino, morpholino-(2-4C)alkylamino, piperazin-1-yl-(2-4C)alkylamino, or 4-(1-4C) alkylpiperazin-1-yl-(2-4C)alkylamino, or pharmaceutically acceptable salts thereof; processes for their preparation, pharmaceutical compositions containing them, and the use of the receptor tyrosine kinase inhibitory properties of the compounds in the treatment of proliferative disease such as cancer.
公开/授权文献
- US4233886A Sealing device for hydraulic piston mechanism 公开/授权日：1980-11-18
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