发明授权
- 专利标题： Thermally stable trimetrexates and processes for producing the same
- 专利标题（中）： 热稳定性三甲氧戊酸及其制备方法
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申请号： US80290申请日： 1998-05-18
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公开(公告)号： US6017922A公开(公告)日： 2000-01-25
- 发明人: Martin Stogniew , Ingomar Grafe , Johann Morsdorf
- 申请人： Martin Stogniew , Ingomar Grafe , Johann Morsdorf
- 申请人地址： PA Conshohocken
- 专利权人： U.S. Bioscience, Inc.
- 当前专利权人： U.S. Bioscience, Inc.
- 当前专利权人地址： PA Conshohocken
- 主分类号： A61K31/517
- IPC分类号： A61K31/517 ; A61P31/04 ; A61P33/10 ; A61P35/00 ; C07D239/95 ; A61K31/505
摘要：
The present invention provides for thermally stable forms of 2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl] quinazoline, or trimetrexate. A crystalline 2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl] quinazoline monohydrate, or trimetrexate monohydrate, belonging to the space group P1(#2) and having a triclinic cell with dimensions of about a=7.699 .ANG., b=9.606 .ANG. and c=13.012 .ANG. is disclosed. A novel Schiff base compound, 2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyphenylimino)-methinyl]quinazoline, is also disclosed. The present invention further provides novel methods of producing stable trimetrexate free base compounds, including crystalline trimetrexate monohydrate. The crystalline monohydrate form provides increased stability over the anhydrous form.
公开/授权文献
- USD411981S Electrical surge protector unit for desk top products 公开/授权日：1999-07-13
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