发明授权
- 专利标题： Human proteasome subunit proteins
- 专利标题（中）： 人类蛋白酶体亚基蛋白
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申请号： US134591申请日： 1998-08-13
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公开(公告)号： US6018028A公开(公告)日： 2000-01-25
- 发明人: Olga Bandman , Janice Au-Young , Jennifer L. Hillman , Surya K. Goli
- 申请人： Olga Bandman , Janice Au-Young , Jennifer L. Hillman , Surya K. Goli
- 申请人地址： CA Palo Alto
- 专利权人： Incyte Pharmaceuticals, Inc.
- 当前专利权人： Incyte Pharmaceuticals, Inc.
- 当前专利权人地址： CA Palo Alto
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C12N1/21 ; C12N9/64 ; C07K14/47
摘要：
The present invention provides polynucleotides which identify and encode novel human proteasome subunit proteins. The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding PSUB. The invention also provides for the use of substantially purified PSUB, antagonists, and in pharmaceutical compositions for the treatment of diseases associated with the expression of PSUB. Additionally, the invention provides for the use of antisense molecules to PSUB in pharmaceutical compositions for treatment of diseases associated with the expression of PSUB. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of polynucleotides encoding PSUB or anti-PSUB antibodies which specifically bind to PSUB.
公开/授权文献
- US5385443A Centrifugal liquid pump with internal gas injection assembly 公开/授权日：1995-01-31
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