发明授权
- 专利标题： Nucleic acid encoding an altered telomere repeat binding factor 2
- 专利标题（中）： 编码改变的端粒重复结合因子2的核酸
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申请号： US273378申请日： 1999-03-22
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公开(公告)号： US6020166A公开(公告)日： 2000-02-01
- 发明人: Titia De Lange , Bas Van Steensel , Alessandro Bianchi
- 申请人： Titia De Lange , Bas Van Steensel , Alessandro Bianchi
- 申请人地址： NY New York
- 专利权人： The Rockfeller University
- 当前专利权人： The Rockfeller University
- 当前专利权人地址： NY New York
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07K14/47 ; C12N1/21 ; C12N15/12 ; C12P21/02 ; C12N1/00 ; C12N5/10 ; C12N15/63
摘要：
The present invention provides an isolated altered vertebrate telomere repeat binding factor (A-TRFs). Also included are the corresponding nucleic acids that encode the A-TRFs of the present invention, as well as the heterodimers formed by the association of an A-TRF with a TRF. In addition, pharmaceutical compositions containing the A-TRFs for treatment of diseases such as ataxia telangiectasia are also included. Methods of making, purifying and using the A-TRFs of the present invention are described. In addition, drug screening assays to identify drugs that mimic and/or complement the effect of the A-TRFs are presented.