发明授权
- 专利标题: Inhibition of viral replication
- 专利标题(中): 抑制病毒复制
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申请号: US795731申请日: 1997-02-05
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公开(公告)号: US6037348A公开(公告)日: 2000-03-14
- 发明人: Joseph Matthew Colacino , Steven Duane Hatch , William Joseph Hornback , Mark Ayer Muesing , John Edwin Munroe , Kirk Alan Staschke , Joseph Chiou-Chung Tang
- 申请人: Joseph Matthew Colacino , Steven Duane Hatch , William Joseph Hornback , Mark Ayer Muesing , John Edwin Munroe , Kirk Alan Staschke , Joseph Chiou-Chung Tang
- 申请人地址: IN Indianapolis
- 专利权人: Eli Lilly and Company
- 当前专利权人: Eli Lilly and Company
- 当前专利权人地址: IN Indianapolis
- 主分类号: A61K45/00
- IPC分类号: A61K45/00 ; A61K31/19 ; A61K31/192 ; A61K31/216 ; A61K31/385 ; A61K31/4409 ; A61K31/4425 ; A61P31/12 ; A61P31/16 ; C12N7/01 ; A01N43/42 ; A01N37/00 ; A61K31/21 ; A61K31/44
摘要:
The present invention provides a method of inhibiting influenza and flaviviral replication based on a mechanism of action in which HA-mediated fusion or E protein mediated fusion is inhibited by a fusion inhibiting agent which binds, complexes or otherwise becomes associated with HA or E protein during the translation of the target protein and/or its vesicular transport.
公开/授权文献
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