发明授权
- 专利标题: Ketoacid endothelin antagonists
- 专利标题(中): 酮酸内皮素拮抗剂
-
申请号: US117575申请日: 1998-07-31
-
公开(公告)号: US6043241A公开(公告)日: 2000-03-28
- 发明人: Xue-Min Cheng , Annette Marian Doherty , Timothy Robert Hurley , Michael James Lovdahl , William Chester Patt , Joseph Thomas Repine
- 申请人: Xue-Min Cheng , Annette Marian Doherty , Timothy Robert Hurley , Michael James Lovdahl , William Chester Patt , Joseph Thomas Repine
- 申请人地址: NJ Morris Plains
- 专利权人: Warner-Lambert Company
- 当前专利权人: Warner-Lambert Company
- 当前专利权人地址: NJ Morris Plains
- 主分类号: C07C59/90
- IPC分类号: C07C59/90 ; C07D317/60 ; A61K31/36 ; C07D317/54
摘要:
Compounds of the Formula I ##STR1## are nonpeptide antagonists of endothelin which are useful in treating a variety of diseasses such as elevated levels of endothelin, acute respiratory distress syndrome (ARDS), atherosclerosis, restenosis, Raynaud's phenomenon etc. The compounds are prepared by reacting an alpha-hydroxy butenolide with one or more equivalents of a suitable base, and exposing the solution to UV light.
公开/授权文献
- US4802801A Worktable support for machine tool 公开/授权日:1989-02-07