发明授权
US6048895A Aromatic C16-C20 substituted tetrahydro prostaglandins useful as FP
agonists
有权
用作FP激动剂的芳族C16-C20取代的四氢前列腺素
- 专利标题： Aromatic C16-C20 substituted tetrahydro prostaglandins useful as FP agonists
- 专利标题（中）： 用作FP激动剂的芳族C16-C20取代的四氢前列腺素
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申请号： US148538申请日： 1998-09-04
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公开(公告)号： US6048895A公开(公告)日： 2000-04-11
- 发明人: John August Wos , Mitchell Anthony deLong , Jack S. Amburgey, Jr. , Haiyan George Dai , Biswanath De , David Lindsey Soper
- 申请人： John August Wos , Mitchell Anthony deLong , Jack S. Amburgey, Jr. , Haiyan George Dai , Biswanath De , David Lindsey Soper
- 申请人地址： OH Cincinnati
- 专利权人： The Procter & Gamble Company
- 当前专利权人： The Procter & Gamble Company
- 当前专利权人地址： OH Cincinnati
- 主分类号： A61K31/5575
- IPC分类号： A61K31/5575 ; A61K31/557 ; A61P19/08 ; A61P19/10 ; A61P27/06 ; A61P43/00 ; C07C59/11 ; C07C69/675 ; C07C229/28 ; C07C259/06 ; C07C317/06 ; C07C321/16 ; C07C405/00 ; A61K31/215 ; C07C69/76
摘要：
The invention provides novel PGF analogs. In particular, the present invention relates to compounds having a structure according to the following formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, X, and Z are as defined. This invention also includes optical isomers, diastereomers and enantiomers of the formula above, and pharmaceutically-acceptable salts, biohydrolyzable amides, esters, and imides thereof.The compounds of the present invention are useful for the treatment of a variety of diseases and conditions, such as bone disorders and glaucoma. Accordingly, the invention further provides pharmaceutical compositions comprising these compounds. The invention still further provides methods of treatment for bone disorders and glaucoma using theses compounds or the compositions containing them.
公开/授权文献
- US4871591A Finish coating method 公开/授权日：1989-10-03