发明授权
- 专利标题： Convergent process for the preparation of a morpholine compound
- 专利标题（中）： 用于制备吗啉化合物的收敛过程
-
申请号： US428783申请日： 1999-10-28
-
公开(公告)号： US6051717A公开(公告)日： 2000-04-18
- 发明人: Dongwei Cai , Michel Journet , Jason Kowal , Robert D. Larson
- 申请人： Dongwei Cai , Michel Journet , Jason Kowal , Robert D. Larson
- 申请人地址： NJ Rahway
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： NJ Rahway
- 主分类号： C07D249/04
- IPC分类号： C07D249/04 ; C07D413/06
摘要：
The present invention is directed to the compound 4-N,N-dimethylaminomethyl-5-formyl-1,2,3-triazole which is a valuable intermediate in the preparation of phamaceutical compounds. The present invention is further directed to a novel convergent process for the preparation of 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)-ethoxy)-4-(5-(dimethylamino)methyl-1,2,3-triazol-4-yl)methyl-3-(S)-(4-fluorophenyl)-morpholine which is a potent and selective substance P (or neurokinin-1) receptor antagonist useful as a therapeutic agent.
公开/授权文献
- US5539908A Dynamically linked and shared compression/decompression 公开/授权日：1996-07-23
信息查询
