发明授权
- 专利标题: Angiogenesis inhibitor
- 专利标题(中): 血管生成抑制剂
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申请号: US740069申请日: 1996-10-24
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公开(公告)号: US6057290A公开(公告)日: 2000-05-02
- 发明人: Chiho Fukiage , Mitsuyoshi Azuma , Jun Inoue , Masayuki Nakamura , Yuka Yoshida
- 申请人: Chiho Fukiage , Mitsuyoshi Azuma , Jun Inoue , Masayuki Nakamura , Yuka Yoshida
- 申请人地址: JPX Osaka
- 专利权人: Senju Pharmaceutical Co., Ltd.
- 当前专利权人: Senju Pharmaceutical Co., Ltd.
- 当前专利权人地址: JPX Osaka
- 优先权: JPX7-277485 19951025; JPX8-248046 19960919
- 主分类号: A61K38/55
- IPC分类号: A61K38/55 ; C07C311/19 ; C07D303/48 ; A61K38/00 ; C07K5/00 ; C07K7/00
摘要:
An angiogenesis inhibitor comprising a cysteine protease inhibitory compound. As the preferable cysteine protease inhibitory compound, epoxysuccinic acid compounds, peptide halohydrazide compounds, calpain inhibitory compounds, compounds of the formula (I) ##STR1## and compounds of the formula (VI) ##STR2## can be used. The angiogenesis inhibitor of the present invention suppresses new formation of blood vessels in the living tissues, so that it can be used as a superior therapeutic or prophylactic agent of angiogenesis associated with wound healing, inflammation, growth of tumor and the like; and angiogenesis as seen in diabetic retinopathy, prematurity retinopathy, retinal venous occlusion, senile discoid macular degeneration and the like, as well as for prevention of metastasis of tumors.
公开/授权文献
- US5259447A Heat transport system 公开/授权日:1993-11-09