- 专利标题： Radiolabeled farnesyl-protein transferase inhibitors
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申请号： US74346申请日： 1998-05-07
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公开(公告)号： US6060038A公开(公告)日： 2000-05-09
- 发明人: Hugh D. Burns , Wai-Si Eng , Raymond E. Gibson
- 申请人： Hugh D. Burns , Wai-Si Eng , Raymond E. Gibson
- 申请人地址： NJ Rahway
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： NJ Rahway
- 主分类号： C07D403/06
- IPC分类号： C07D403/06 ; A61K31/496 ; A61K51/00 ; A61K51/04 ; C07D233/56 ; C12Q1/48 ; C07D241/00
摘要：
The present invention is directed toward radiolabeled farnesyl-protein transferase inhibitor compounds which are useful to label FPTase in assays, whether cell-based, tissue-based or in whole animal. The tracers can also be used in competitive binding assays to obtain information on the interaction of unlabeled FTIs with FPTase.