发明授权
- 专利标题： Integrin receptor antagonists
- 专利标题（中）： 整合素受体拮抗剂
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申请号： US212123申请日： 1998-12-15
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公开(公告)号： US06066648A公开(公告)日： 2000-05-23
- 发明人: Mark E. Duggan , Robert S. Meissner , James J. Perkins
- 申请人： Mark E. Duggan , Robert S. Meissner , James J. Perkins
- 申请人地址： NJ Rahway
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： NJ Rahway
- 主分类号： A61K31/66
- IPC分类号： A61K31/66 ; A61K45/06 ; C07D401/14 ; C07D471/04 ; C07D519/00 ; A01N43/40
摘要：
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as vitronectin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the vitronectin receptors .alpha..nu..beta.3 and/or .alpha..nu..beta.5 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, viral disease, and tumor growth.