发明授权
- 专利标题： 4-phenyl-3-substituted 1,4-dihydropyridine esters
- 专利标题（中）： 4-苯基-3-取代的1,4-二氢吡啶酯
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申请号： US988114申请日： 1997-12-10
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公开(公告)号： US6066655A公开(公告)日： 2000-05-23
- 发明人: Heinrich Meier , Wolfgang Hartwig , Bodo Junge , Rudolf Schohe-Loop , Zhan Gao , Bernard Schmidt , Maarten de Jonge , Teunis Schuurman
- 申请人： Heinrich Meier , Wolfgang Hartwig , Bodo Junge , Rudolf Schohe-Loop , Zhan Gao , Bernard Schmidt , Maarten de Jonge , Teunis Schuurman
- 申请人地址： DEX Leverkusen
- 专利权人： Bayer Aktiengesellschaft
- 当前专利权人： Bayer Aktiengesellschaft
- 当前专利权人地址： DEX Leverkusen
- 优先权： DEX4342196 19931210
- 主分类号： A61K31/4427
- IPC分类号： A61K31/4427 ; A61K31/455 ; A61P9/08 ; A61P25/24 ; A61P25/26 ; A61P25/28 ; C07D211/90 ; C07D401/12 ; C07D211/86
摘要：
4-Phenyl-3-substituted 1,4-dihydropyridine esters are prepared by reaction of benzaldehydes with ketoesters and enamines, if appropriate with isolation of the ylidene intermediate products, or by esterification of corresponding dihydropyridinecarboxylic acids with alcohols.The new 4-phenyl-3-substituted 1,4-dihydropyridine esters can be employed as active compounds in medicaments for the treatment of the central nervous system, in particular as cerebral therapeutics.
公开/授权文献
- US5351997A Pipe coupling 公开/授权日：1994-10-04