发明授权
- 专利标题: Amino compounds and angiotensin IV receptor agonists
- 专利标题(中): 氨基化合物和血管紧张素IV受体激动剂
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申请号: US101449申请日: 1998-07-16
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公开(公告)号: US6066672A公开(公告)日: 2000-05-23
- 发明人: Takeo Kobori , Kenichi Goda , Kikuo Sugimoto , Tomomi Ota , Kazuyuki Tomisawa
- 申请人: Takeo Kobori , Kenichi Goda , Kikuo Sugimoto , Tomomi Ota , Kazuyuki Tomisawa
- 申请人地址: JPX Tokyo JPX Sagamihara
- 专利权人: Taisho Pharmaceutical Co., Ltd.,Sagami Chemical Research Center
- 当前专利权人: Taisho Pharmaceutical Co., Ltd.,Sagami Chemical Research Center
- 当前专利权人地址: JPX Tokyo JPX Sagamihara
- 优先权: JPX8-207010 19960806
- 主分类号: C07C237/20
- IPC分类号: C07C237/20 ; C07D213/40 ; C07D215/12 ; A61K31/165 ; C07C233/05
摘要:
The present invention provides an amino compound represented by Formula: ##STR1## wherein X is CH.sub.2 NH or CONH, Y is CH.sub.2 NH or CONH with the proviso that X and Y are not CONH at the same time; Z is CH.dbd.C(R.sup.4)R.sup.5, CH.sub.2 CH(R.sup.4)R.sup.5 or an alkoxycarbonyl group, R.sup.1 is a hydrogen atom; a lower alkyl group, a cycloalkyl group, a cycloalkyl-substituted alkyl group, an aralkyl group or an aryl group, each group of which is substituted or unsubstituted, R.sup.2 and R.sup.3 are each independently a lower alkyl group or an aralkyl group, each group of which is substituted or unsubstituted, and R.sup.4 and R.sup.5 are each independently a hydrogen atom; an alkyl group, an aralkyl group, an aryl group or a heteroaryl group, each group of which is substituted or unsubstituted, or a pharmaceutically acceptable salt thereof; a medicine comprising the amino compound of Formula (1) or a pharmaceutically acceptable salt; and an angiotensin IV receptor agonist containing the same as an effective component, which are useful, in particular, as a therapeutical drug (antagonist or agonist) for various diseases in which angiotensin IV participates, for example, acceleration of renal blood flow, cerebral vasodilation, inhibition of cell proliferation and hypermnesia.
公开/授权文献
- US5592203A Ink jet print head 公开/授权日:1997-01-07
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