发明授权
- 专利标题： Intermediates for the preparation of duocarmycin SA and derivatives thereof, and process for the production of the intermediates
- 专利标题（中）： 制备杜卡霉素SA及其衍生物的中间体，以及生产中间体的方法
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申请号： US254515申请日： 1999-03-09
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公开(公告)号： US6066742A公开(公告)日： 2000-05-23
- 发明人: Yasumichi Fukuda , Shiro Terashima
- 申请人： Yasumichi Fukuda , Shiro Terashima
- 申请人地址： JPX Tokyo JPX Kanagawa
- 专利权人： Kyorin Pharmaceutical Co., Ltd.,Sagami Chemical Research Center
- 当前专利权人： Kyorin Pharmaceutical Co., Ltd.,Sagami Chemical Research Center
- 当前专利权人地址： JPX Tokyo JPX Kanagawa
- 优先权： JPX8-246097 19960918
- 主分类号： A61K31/40
- IPC分类号： A61K31/40 ; A61K31/403 ; A61K31/404 ; A61P35/00 ; C07D209/12 ; C07D487/04
摘要：
Indole derivatives shown by the formulae (1), (2a) and (2b) ##STR1## (wherein R.sup.1 is a protecting group for amino group; R.sup.2 is a protecting group for hydroxyl group; R.sup.3 is a protecting group for hydroxyl group; R.sup.4 is a C.sub.1 -C.sub.6 linear or branched lower alkyl group, or benzyl group), and pyrroloindole derivatives shown by formula (3) ##STR2## (wherein R.sup.1 is a protecting group for amino group; R.sup.2 is a protecting group for hydroxyl group; R.sup.3 is a protecting group for hydroxyl group; R.sup.4 is a C.sub.1 -C.sub.6 linear or branched lower alkyl group, or benzyl group), both of which are intermediates for duocarmycin SA, which is expected to be used as an anticancer agent, and derivatives thereof; and a method for producing the same.
公开/授权文献
- US5780157A Composite structure 公开/授权日：1998-07-14