发明授权
- 专利标题： Compounds that inhibit the binding of integrins to their receptors
- 专利标题（中）： 抑制整联蛋白与其受体结合的化合物
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申请号： US292459申请日： 1999-04-15
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公开(公告)号： US6096773A公开(公告)日： 2000-08-01
- 发明人: Ian L. Scott , Bore G. Raju , Ronald J. Biediger , Vanessa O. Grabbe , Jamal Kassir , Karin M. Keller , Timothy P. Kogan, deceased , Shuqun Lin , Robert V. Market
- 申请人： Ian L. Scott , Bore G. Raju , Ronald J. Biediger , Vanessa O. Grabbe , Jamal Kassir , Karin M. Keller , Timothy P. Kogan, deceased , Shuqun Lin , Robert V. Market
- 申请人地址： TX Houston
- 专利权人： Texas Biotechnology Corporation, Inc.
- 当前专利权人： Texas Biotechnology Corporation, Inc.
- 当前专利权人地址： TX Houston
- 主分类号： C07D317/44
- IPC分类号： C07D317/44 ; A61K31/16 ; A61K31/357 ; A61K31/36 ; A61K31/38 ; A61K31/381 ; A61K31/404 ; A61K31/4184 ; A61K31/425 ; A61K31/427 ; A61K31/443 ; A61K31/4433 ; A61K31/4525 ; A61K31/495 ; A61K31/496 ; A61K31/5377 ; A61P1/04 ; A61P3/10 ; A61P9/10 ; A61P11/06 ; A61P17/00 ; A61P19/02 ; A61P25/00 ; A61P29/00 ; A61P35/00 ; A61P35/02 ; A61P37/06 ; A61P37/08 ; A61P43/00 ; C07C233/00 ; C07D233/02 ; C07D277/30 ; C07D317/60 ; C07D333/20 ; C07D333/24 ; C07D333/36 ; C07D405/00 ; C07D405/12 ; C07D405/14 ; C07D409/00 ; C07D409/12 ; C07D409/14 ; C07D413/14 ; C07D417/14 ; A61K31/19 ; A61K31/41 ; C07D317/50
摘要：
A method for the inhibition of the binding of .alpha..sub.4 .beta..sub.1 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions comprising such compounds; and the use of such compounds either as above, or in formulations for the control or prevention of diseases states in which .alpha..sub.4 .beta..sub.1 is involved.
公开/授权文献
- US5465910A Overmolded cover for fuel injector power group and method 公开/授权日：1995-11-14