发明授权
- 专利标题: Epoxysuccinamide derivative or salt thereof
- 专利标题(中): 环氧琥珀酰胺衍生物或其盐
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申请号: US202607申请日: 1998-12-17
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公开(公告)号: US6110967A公开(公告)日: 2000-08-29
- 发明人: Tetsuji Asao , Tomohiro Yamashita , Yoshimitsu Suda , Shigeo Okajima , Yukio Tada , Nobuhiko Katsunuma , Shozo Yamada , Kazuhiko Shigeno , Atsuhiko Uemura
- 申请人: Tetsuji Asao , Tomohiro Yamashita , Yoshimitsu Suda , Shigeo Okajima , Yukio Tada , Nobuhiko Katsunuma , Shozo Yamada , Kazuhiko Shigeno , Atsuhiko Uemura
- 申请人地址: JPX Tokyo
- 专利权人: Taiho Pharmaceuticals Co., Ltd.
- 当前专利权人: Taiho Pharmaceuticals Co., Ltd.
- 当前专利权人地址: JPX Tokyo
- 优先权: JPX9-102151 19970418
- 主分类号: C07D303/40
- IPC分类号: C07D303/40 ; C07D303/48 ; A61K31/495 ; A61K31/41 ; A61K31/435
摘要:
The invention relates an epoxysuccinamide derivative represented by a formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom, an alkyl or aminoalkyl group, R.sup.2 represents an aminoalkyl group which May be substituted, an aryl group which may be substituted, a heterocyclic group which may be substituted, an aralkyl group which may be substituted, or an alkyl group substituted by a heterocyclic ring which may be substituted, or R.sup.1 and R.sup.2 may form a nitrogen-containing heterocyclic ring, which may be substituted, together with the adjacent nitrogen atoms, and R.sup.3 and R.sup.4 are the same or different from each other and independently represent a hydrogen atom, or an alkyl or aralkyl group, or a salt thereof, a preparation process thereof, and a medicine comprising such a derivative or salt as an active ingredient. This compound has a specific inhibitory activity for cathepsin L and family enzymes thereof, and is useful as an agent for preventing and treating metabolic osteopathy such as osteoporosis and hypercalcemia.
公开/授权文献
- US5430212A Olefin oligomerization 公开/授权日:1995-07-04
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