发明授权
- 专利标题: Phenylsubstituted 4-azasteroid fluoroderivatives
- 专利标题(中): 苯基取代的4-azasteroid氟代衍生物
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申请号: US300454申请日: 1999-04-28
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公开(公告)号: US6114345A公开(公告)日: 2000-09-05
- 发明人: Achille Panzeri , Marcella Nesi , Enrico Di Salle
- 申请人: Achille Panzeri , Marcella Nesi , Enrico Di Salle
- 申请人地址: ITX Milan
- 专利权人: Pharmacia & Upjohn, S.p.A.
- 当前专利权人: Pharmacia & Upjohn, S.p.A.
- 当前专利权人地址: ITX Milan
- 优先权: GBX9518858 19950914
- 主分类号: A61K31/58
- IPC分类号: A61K31/58 ; A61P43/00 ; C07J73/00
摘要:
Compounds of formula (I), wherein: the symbol ---- represents a single or a double bond; R is a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group; R.sub.f and R'.sub.f, each independently, are C.sub.1 -C.sub.4 alkyl groups substituted by one or more fluorine atoms; and R.sub.1 and R.sub.2, each independently, are selected from: a hydrogen atom; a phenyl group; a C.sub.1 -C.sub.4 alkyl group unsubstituted or substituted by one or more fluorine atoms; a halogen atom; a cyano (CN) group; a group OR.sub.4, wherein R.sub.4 is a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group; a group SR.sub.5, wherein R.sub.5 is a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group; and a group COR.sub.6, wherein R.sub.6 is a group OR.sub.4 in which R.sub.4 is as defined above or a C.sub.1 -C.sub.4 alkyl group unsubstituted or substituted by one or more fluorine atoms. They are useful as testosterone 5a-reductase inhibitors.
公开/授权文献
- US5492675A Deodorant system 公开/授权日:1996-02-20
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