Invention Grant
- Patent Title: Method for preparing a tetrahydropyridin derivative
- Patent Title (中): 四氢吡啶衍生物的制备方法
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Application No.: US331521Application Date: 1999-06-22
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Publication No.: US6118006APublication Date: 2000-09-12
- Inventor: Michel Buj , Robert Filhol
- Applicant: Michel Buj , Robert Filhol
- Applicant Address: FRX Paris
- Assignee: Sanofi-Synthelabo
- Current Assignee: Sanofi-Synthelabo
- Current Assignee Address: FRX Paris
- Priority: FRX9615906 19961223
- Main IPC: A61K31/44
- IPC: A61K31/44 ; C07C17/16 ; C07C22/04 ; C07C29/147 ; C07C33/18 ; C07D211/70 ; C07D211/72 ; C07D211/84
Abstract:
The invention relates to a method for the preparation of 1-[2-(2-naphthyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine and its pharmaceutically acceptable salts by reacting 2-(2-bromoethyl)naphthalene with 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine or one of its salts, and to a universal method for the preparation of the same product and its salts by the reduction of naphthylacetic acid, treatment of the resulting 2-naphthylethanol with hydrobromic acid and treatment of the 2-(2-bromoethyl)naphthalene with 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine or one of its salts.
Public/Granted literature
- US5658341A Tibial implant for a knee prosthesis Public/Granted day:1997-08-19
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