发明授权
- 专利标题: Cyanoguanidines as cell proliferation inhibitors
- 专利标题(中): 氰基胍作为细胞增殖抑制剂
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申请号: US424655申请日: 1999-11-26
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公开(公告)号: US6121297A公开(公告)日: 2000-09-19
- 发明人: Erik Rytter Ottosen
- 申请人: Erik Rytter Ottosen
- 申请人地址: DKX Ballerup
- 专利权人: Leo Pharmaceutical Products Ltd. A/S
- 当前专利权人: Leo Pharmaceutical Products Ltd. A/S
- 当前专利权人地址: DKX Ballerup
- 优先权: GBX9711119 19970529
- 主分类号: C07D213/74
- IPC分类号: C07D213/74 ; A61K31/44 ; A61P17/06 ; A61P35/00 ; A61P43/00 ; C07D213/75
摘要:
The present invention relates to hitherto unknown compounds of formula (I) or their tautomeric forms, the attachment to the pyridine ring being in the 3- or 4-position, in which formula R.sub.1 stands for one or more substituents which can be the same or different and are selected from the group consisting of: hydrogen, halogen, trifluoromethyl, carboxy, C.sub.1 -C.sub.4 alkyl, alkoxy or alkoxycarbonyl, nitro, amino or cyano and Q stands for C.sub.9 -C.sub.20 divalent hydrocarbon radical which can be saturated, straight or branched or Q stands for C.sub.4 -C.sub.20 divalent hydrocarbon radical which can be cyclic or unsaturated and X stands for oxygen, sulfur or nitrogen the latter optionally being substituted by hydrogen or C.sub.1 -C.sub.4 alkyl and R.sub.2 stands for one or more substituents which can be the same or different and are selected from the group consisting of: hydrogen, C.sub.1 -C.sub.4 alkyl or alkoxy, hydroxy, halogen, trifluoromethyl, cyano, carboxamido, sulfamoyl or nitro; and pharmaceutically acceptable, non-toxic salts and N-oxides thereof. The present compounds are of value in the human and veterinary practice. ##STR1##
公开/授权文献
- US5551347A Human amusement ride 公开/授权日:1996-09-03
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