发明授权
- 专利标题: N-[4-(Heteroarylmethyl)phenyl]-heteroarylamines
- 专利标题(中): N- [4-(杂芳基甲基)苯基] - 杂芳基胺
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申请号: US214080申请日: 1999-04-29
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公开(公告)号: US6124330A公开(公告)日: 2000-09-26
- 发明人: Marc Gaston Venet , Dominique Jean-Pierre Mabire , Jean Fernand Armand Lacrampe , Gerard Charles Sanz
- 申请人: Marc Gaston Venet , Dominique Jean-Pierre Mabire , Jean Fernand Armand Lacrampe , Gerard Charles Sanz
- 申请人地址: FRX Issy-les-Moulineaux Cedex
- 专利权人: Janssen-Cilag S.A.
- 当前专利权人: Janssen-Cilag S.A.
- 当前专利权人地址: FRX Issy-les-Moulineaux Cedex
- 优先权: EPX96201781 19960627
- 主分类号: C07D473/34
- IPC分类号: C07D473/34 ; A61K31/00 ; A61K31/41 ; A61K31/415 ; A61K31/4164 ; A61K31/4184 ; A61K31/42 ; A61K31/423 ; A61K31/425 ; A61K31/427 ; A61K31/435 ; A61K31/4353 ; A61K31/437 ; A61K31/44 ; A61K31/4427 ; A61K31/4439 ; A61K31/445 ; A61K31/4465 ; A61K31/4523 ; A61K31/454 ; A61K31/47 ; A61K31/472 ; A61K31/4725 ; A61K31/495 ; A61K31/496 ; A61K31/4965 ; A61K31/497 ; A61K31/498 ; A61K31/50 ; A61K31/501 ; A61K31/502 ; A61K31/505 ; A61K31/506 ; A61K31/517 ; A61K31/519 ; A61K31/52 ; A61K31/529 ; A61K31/535 ; A61K31/5375 ; A61K31/5377 ; A61P17/00 ; A61P17/06 ; A61P35/00 ; A61P43/00 ; C07D277/22 ; C07D401/12 ; C07D403/12 ; C07D413/12 ; C07D417/12 ; C07D513/04 ; C07D521/00 ; A61K31/426 ; C07D277/60 ; C07D417/10
摘要:
The present invention is concerned with compounds of formula ##STR1## the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein R.sup.1 is hydrogen, hydroxy, C.sub.1-6 alkyl or aryl; R.sup.2 is hydrogen; optionally substituted C.sub.1-12 alkyl; C.sub.3-7 cycloalkyl; C.sub.2-8 alkenyl, optionally substituted pyrrolidinyl or aryl; R.sup.3 is hydrogen, optionally substituted C.sub.1-6 alkyl or aryl; Het is an optionally substituted unsaturated heterocycle selected from imidazolyl, triazolyl, tetrazolyl and pyridinyl; ##STR2## is an optionally substituted unsaturated mono- or bicyclic heterocycle; and aryl is optionally substituted phenyl. The present invention also relates to processes for their preparation and compositions comprising said new compounds, as well as their use as a medicine.
公开/授权文献
- US5373806A Particulate-free epitaxial process 公开/授权日:1994-12-20