Invention Grant
- Patent Title: Muteins of IFN-.beta.
- Patent Title (中): IFN-β的突变蛋白
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Application No.: US912768Application Date: 1997-08-18
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Publication No.: US6127332APublication Date: 2000-10-03
- Inventor: Susan E. Goelz , Richard L. Cate , E. Pingchang Chow , R. Blake Pepinsky
- Applicant: Susan E. Goelz , Richard L. Cate , E. Pingchang Chow , R. Blake Pepinsky
- Applicant Address: MA Cambridge
- Assignee: Biogen, Inc.
- Current Assignee: Biogen, Inc.
- Current Assignee Address: MA Cambridge
- Main IPC: C12N15/09
- IPC: C12N15/09 ; A61K38/00 ; A61K38/21 ; A61K48/00 ; A61P31/12 ; A61P35/00 ; A61P37/00 ; A61P43/00 ; C07H21/04 ; C07K14/565 ; C12N1/21 ; C12N15/24 ; C12P21/02 ; C12R1/19
Abstract:
A IFN-.beta. mutein in which phe (F), tyr (Y), trp (W) or his (H) is substituted for val (V) at position 101, when numbered in accordance with wild type IFN-.beta., DNA sequences encoding these IFN-.beta. muteins, recombinant DNA molecules containing those DNA sequences operatively linked to expression control sequences and capable of inducing expression of an IFN-.beta. mutein, hosts transformed with those recombinant DNA molecules, pharmaceutical compositions containing IFN-.beta. muteins and methods for treating viral infections, cancer or tumors, undesired cell proliferation, or for immunomodulation.
Public/Granted literature
- US4749682A Perfume compositions and perfumed products which contain an alkyl 2-mercaptobenzoate as fragrance material Public/Granted day:1988-06-07
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