Invention Grant
US6130065A Nitrobenzylmercaptopurineriboside (NBMPR)-insensitive, equilibrative,
nucleoside transport protein, nucleic acids encoding the same and
methods of use
失效
硝基苄基巯基嘌呤苷（NBMPR） - 敏感，平衡，核苷转运蛋白，编码相同的核酸和使用方法
- Patent Title: Nitrobenzylmercaptopurineriboside (NBMPR)-insensitive, equilibrative, nucleoside transport protein, nucleic acids encoding the same and methods of use
- Patent Title (中): 硝基苄基巯基嘌呤苷（NBMPR） - 敏感，平衡，核苷转运蛋白，编码相同的核酸和使用方法
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Application No.: US58389Application Date: 1998-04-09
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Publication No.: US6130065APublication Date: 2000-10-10
- Inventor: Judith A. Belt , Charles R. Crawford
- Applicant: Judith A. Belt , Charles R. Crawford
- Applicant Address: TN Memphis
- Assignee: St. Jude Children's Research Hospital
- Current Assignee: St. Jude Children's Research Hospital
- Current Assignee Address: TN Memphis
- Main IPC: C07K14/705
- IPC: C07K14/705 ; C12N15/12 ; C12P21/06
Abstract:
An isolated NBMPR-insensitive equilibrative nucleoside transport protein (iENTP) and the nucleic acid encoding it is disclosed. The iENTP can be used in screening assays to identify both natural nucleoside permeants and/or inhibitors and analogs thereof. In addition, transfected or transduced cell lines are disclosed which use the iENTP as the sole nucleoside transport protein. Methods of employing such cell lines for drug screening are also included. Furthermore methods of using hematopoietic stem cells transduced with an iENTP in a chemotherapy protocol is also described. In addition, methods of using these cells to selectively express a heterologous gene for gene therapy is disclosed.
Public/Granted literature
- USD389650S Bottom for a golf bag Public/Granted day:1998-01-27
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