Invention Grant
- Patent Title: Combined tissue factor and chemotherapeutic methods and compositions for coagulation and tumor treatment
- Patent Title (中): 组合因子和化学治疗方法和组合物用于凝血和肿瘤治疗
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Application No.: US9217Application Date: 1998-01-20
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Publication No.: US6132729APublication Date: 2000-10-17
- Inventor: Philip E. Thorpe , Steven W. King , Boning Gao
- Applicant: Philip E. Thorpe , Steven W. King , Boning Gao
- Applicant Address: TX Austin
- Assignee: Board of Regents, The University of Texas System
- Current Assignee: Board of Regents, The University of Texas System
- Current Assignee Address: TX Austin
- Main IPC: A61K45/00
- IPC: A61K45/00 ; A61K38/00 ; A61K47/48 ; A61P7/02 ; A61P35/00 ; A61K39/00 ; A61K39/395 ; C07K14/00 ; C07K35/14
Abstract:
The invention embodies the surprising discovery that Tissue Factor (TF) compositions and variants thereof specifically localize to the blood vessels within a vascularized tumor following systemic administration. The invention therefore provides methods and compositions comprising coagulation-deficient Tissue Factor for use in effecting specific coagulation and for use in tumor treatment. The TF compositions and methods of present invention may be used alone, as TF conjugates with improved half-life, or in combination with other agents, such as conventional chemotherapeutic drugs, targeted immunotoxins, targeted coaguligands, and/or in combination with Factor VIIa (FVIIa) or FVII activators.
Public/Granted literature
- USD353335S Plastic bottle Public/Granted day:1994-12-13
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