Invention Grant
- Patent Title: Combined tissue factor and factor VIIa methods and compositions for coagulation and tumor treatment
- Patent Title (中): 组合因子和凝血因子Ⅶa组合物用于凝血和肿瘤治疗
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Application No.: US9656Application Date: 1998-01-20
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Publication No.: US6132730APublication Date: 2000-10-17
- Inventor: Philip E. Thorpe , Steven W. King , Boning Gao
- Applicant: Philip E. Thorpe , Steven W. King , Boning Gao
- Applicant Address: TX Austin
- Assignee: Board of Regents, The University of Texas System
- Current Assignee: Board of Regents, The University of Texas System
- Current Assignee Address: TX Austin
- Main IPC: A61K45/00
- IPC: A61K45/00 ; A61K38/00 ; A61K47/48 ; A61P7/02 ; A61P35/00 ; A61K39/00 ; A61K35/14 ; A61K39/395 ; C07K14/00
Abstract:
The invention embodies the surprising discovery that Tissue Factor (TF) compositions and variants thereof specifically localize to the blood vessels within a vascularized tumor following systemic administration. The invention therefore provides methods and compositions comprising coagulation-deficient Tissue Factor for use in effecting specific coagulation and for use in tumor treatment. The TF compositions and methods of present invention may be used alone, as TF conjugates with improved half-life, or in combination with other agents, such as conventional chemotherapeutic drugs, targeted immunotoxins, targeted coaguligands, and/or in combination with Factor VIIa (FVIIa) or FVII activators.
Public/Granted literature
- USD356229S Pedestal mounted drinking fountain Public/Granted day:1995-03-14
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